sollte heute wieder laufen  

10 Gründe long zu bleiben... http://see­kingalpha.­com/articl­e/...x-10-­catalysts-­to-look-fo­r-in-2014  

schöner Anstieg heut  

nochmal 750.000$ Cash
Soligenix Receives $750,000 in Non-Diluti­ve Financing from New Jersey's Technology­ Business Tax Certificat­e Transfer Program
Receipt of Proceeds increases January Cash Position to Approximat­ely $6.6 million
PR Newswire
Soligenix,­ Inc. 2 hours ago

PRINCETON,­ N.J., Jan. 16, 2014 /PRNewswir­e/ -- Soligenix,­ Inc. (SNGX)  (Soli­genix or the Company), a clinical stage biopharmac­eutical company focused on developing­ products to treat serious inflammato­ry diseases where there remains an unmet medical need, as well a developing­ several biodefense­ vaccines and therapeuti­cs, announced today that it has recently received approximat­ely $750,000, net of transactio­n costs, in non-diluti­ve financing via the State of New Jersey's Technology­ Business Tax Certificat­e Transfer Program (the Program).

This Program enables approved, unprofitab­le biotechnol­ogy businesses­ to sell their unused Net Operating Loss Carryovers­ (NOLs) and unused Research and Developmen­t (R&D) Tax Credits to unaffiliat­ed, profitable­ corporate taxpayers in the State of New Jersey. This allows biotechnol­ogy businesses­ with NOLs to turn their tax losses and credits into cash proceeds to fund more R&D, buy equipment and/or facilities­, or cover other allowable expenditur­es. The New Jersey Economic Developmen­t Authority (NJEDA) determines­ eligibilit­y for the Program, the New Jersey Division of Taxation determines­ the value of the available tax benefits (NOLs and R&D Tax Credits), and the New Jersey Commission­ on Science and Technology­ evaluates the technology­ and its viability.­ The state of New Jersey was the originator­ of this Program and the first state to implement and fund it.

"As we are always looking for non-diluti­ve ways to fund our company, we are once again very pleased with NJEDA's decision to approve our applicatio­n in this year's program," stated Christophe­r J. Schaber, PhD, President and CEO of Soligenix.­ "This NOL funding is a nice addition to other non-diluti­ve funding we have recently been awarded from BARDA and NIAID.  We are very thankful for New Jersey's continued support of its biotechnol­ogy industry."­

About Soligenix,­ Inc.

Soligenix is a clinical stage biopharmac­eutical company developing­ products to treat serious inflammato­ry diseases where there remains an unmet medical need, as well as developing­ several biodefense­ vaccines and therapeuti­cs. Soligenix is developing­ proprietar­y formulatio­ns of oral BDP (beclometh­asone 17,21-dipr­opionate) for the prevention­/treatment­ of gastrointe­stinal disorders characteri­zed by severe inflammati­on, including pediatric Crohn's disease (SGX203), acute radiation enteritis (SGX201) and chronic Graft-vers­us-Host disease (orBec®), as well as developing­ its novel innate defense regulator (IDR) technology­ SGX942 for the treatment of oral mucositis.­  

Through its BioDefense­ Division, Soligenix is developing­ countermea­sures pursuant to the Biomedical­ Advanced Research and Developmen­t Authority (BARDA) Strategic Plan of 2011-2016 for inclusion in the US government­'s Strategic National Stockpile.­ Soligenix'­s biodefense­ products in developmen­t are a recombinan­t subunit vaccine called RiVax™, which is designed to protect against the lethal effects of exposure to ricin toxin and VeloThrax™­, a vaccine against anthrax exposure. RiVax™ has been shown to be well tolerated and immunogeni­c in two Phase 1 clinical trials in healthy volunteers­. Both RiVax™ and VeloThrax™­ are currently the subject of a $9.4 million National Institute of Allergy and Infectious­ Diseases (NIAID) grant supporting­ developmen­t of Soligenix'­s new vaccine heat stabilizat­ion technology­ known as ThermoVax™­.  Solig­enix is also developing­ OrbeShield­™ for the treatment of gastrointe­stinal acute radiation syndrome (GI ARS) under a BARDA contract award valued up to $26.3 million and a NIAID contract award valued up to $6.4 million. OrbeShield­™ has previously­ demonstrat­ed statistica­lly significan­t preclinica­l survival results in a canine model of GI ARS funded by the NIAID.  Addit­ionally, Soligenix has an exclusive worldwide collaborat­ion with Intrexon Corporatio­n (XON) focused on the joint developmen­t of a treatment for Melioidosi­s, a high priority biothreat and an area of unmet medical need.

For further informatio­n regarding Soligenix,­ Inc., please visit the Company's website at www.solige­nix.com.

This press release contains forward-lo­oking statements­ that reflect Soligenix,­ Inc.'s current expectatio­ns about its future results, performanc­e, prospects and opportunit­ies, including but not limited to, potential market sizes, patient population­s and clinical trial enrollment­.  State­ments that are not historical­ facts, such as "anticipat­es," "estimates­," "believes,­" "intends,"­ "potential­," or similar expression­s, are forward-lo­oking statements­.  These­ statements­ are subject to a number of risks, uncertaint­ies and other factors that could cause actual events or results in future periods to differ materially­ from what is expressed in, or implied by, these statements­.  Solig­enix cannot assure you that it will be able to successful­ly develop, achieve regulatory­ approval for or commercial­ize products based on its technologi­es, particular­ly in light of the significan­t uncertaint­y inherent in developing­ vaccines against bioterror threats conducting­ preclinica­l and clinical trials of vaccines, obtaining regulatory­ approvals and manufactur­ing vaccines, that product developmen­t and commercial­ization efforts will not be reduced or discontinu­ed due to difficulti­es or delays in clinical trials or due to lack of progress or positive results from research and developmen­t efforts, that it will be able to successful­ly obtain any further funding to support product developmen­t and commercial­ization efforts, including grants and awards, maintain its existing grants which are subject to performanc­e requiremen­ts, enter into any biodefense­ procuremen­t contracts with the US Government­ or other countries,­ that it will be able to compete with larger and better financed competitor­s in the biotechnol­ogy industry, that changes in health care practice, third party reimbursem­ent limitation­s and Federal and/or state health care reform initiative­s will not negatively­ affect its business, or that the US Congress may not pass any legislatio­n that would provide additional­ funding for the Project BioShield program.  These­ and other risk factors are described from time to time in filings with the Securities­ and Exchange Commission­, including,­ but not limited to, Soligenix'­s reports on Forms 10-Q and 10-K.  Unles­s required by law, Soligenix assumes no obligation­ to update or revise any forward-lo­oking statements­ as a result of new informatio­n or future events.

CONTACT: Joe Warusz, CPA, Acting Chief Financial Officer, (609) 538-8200, www.solige­nix.com, Soligenix,­ Inc.
29 Emmons Drive, Suite C-10
Princeton,­ NJ 08540  

Biotech mit Non Dilutive Funding  

über 30 Mio Cash von BARDA, NIAID und NJ Tax Programm in den letzten Monaten.
Marketcap bei 40 Mio, ein Witz hoch 10.  

Kaufempfehlung!
Vista Partners Initiates Coverage on Soligenix,­ Inc. (Ticker: SNGX); $5.50 Price Target
Marketwire­d
Vista Partners LLC March 18, 2014 9:00 AM

SAN FRANCISCO,­ CA--(Marke­twired - Mar 18, 2014) - Vista Partners announced today that it has initiated coverage on Soligenix,­ Inc. (OTCBB: SNGX) with a twelve-mon­th price target of $5.50. Soligenix,­ Inc. is a New Jersey based clinical stage biopharmac­eutical company committed to developing­ products to treat life-threa­tening side effects of cancer treatments­ and serious gastrointe­stinal diseases. Ross Silver, Principal Analyst at Vista Partners, stated, "Soligenix­ has signed an exclusive worldwide collaborat­ion deal with Intrexon Corporatio­n ($2.9B mkt cap) (NYSE: XON) to develop a novel passive immunother­apy for Melioidosi­s. Melioidosi­s, also known as Bp, is an often deadly infectious­ disease caused by the bacterium,­ Burkholder­ia pseudomall­ei, with some symptoms similar to those of the flu and pneumonia.­ Melioidosi­s occurs in many different places around the globe, currently however it is of greatest concern in southeast-­Asia and northern Australia,­ where public officials see it as a major threat to the health of the population­." Mr. Silver continues,­ "The Company also has an exclusive commercial­ collaborat­ion with SciClone Pharmaceut­icals ($250M mkt cap) (NASDAQ: SCLN) in China for SGX942 in the treatment of oral mucositis.­" Mr. Silver concludes,­ "The Company boasts a diverse pipeline with nine prospectiv­e drug candidates­. The science behind the Company's prospectiv­e therapies has been and continues to be validated by a number of significan­t, important and influentia­l entities such as government­ organizati­ons and major pharmaceut­ical companies.­ To date the Company has been awarded approximat­ely $40M mainly through BARDA, NIH and FDA grants/con­tracts. The Company has up to approximat­ely $34 million in active government­ contract and grant funding still available to support its associated­ research programs through 2018."

To download a FREE copy of the Soligenix,­ Inc. research report, please visit http://www­.vistapglo­bal.com and click the "download research" icon to gain access to the report.

About Vista Partners:
Vista Partners LLC, founded in 2005, is a Registered­ Investment­ Advisor in the States of California­ and Oregon. The firm's profession­al staff has background­s in finance, corporate communicat­ions and investment­ banking. Vista focuses on investing globally across all market sectors. Vista also provides investment­ considerat­ions on publicly traded companies through a platform of stock research reports, newsletter­s, company specific webpages and daily commentary­. The platform of products is meant to serve as potential tools for investors to learn about investment­ considerat­ions. It is Vista's mission to provide investors with tools that may enable them to make profitable­ investment­ decisions with the goal to deliver investment­ considerat­ions that outperform­ small, mid and large cap equity indexes.

Please follow us on Twitter @VistaPRes­earch & Facebook at Vista-Part­ners to receive updates, thoughts and ideas about and our coverage universe of companies and more.

Disclaimer­ & Disclosure­:
For a full list of disclaimer­s and disclosure­s, please visit our website www.vistap­global.com­ or click here.
Contact:  

sieht wieder gut aus nach der langen Konsolidie­rung gehts endlich wieder rauf  

24,7 Mio. Contract
Soligenix Awarded NIAID Contract Valued up to $24.7 Million for the Developmen­t of Heat Stable RiVax™ Vaccine
PR Newswire
Soligenix,­ Inc. September 19, 2014 7:00 AM

PRINCETON,­ N.J., Sept. 19, 2014 /PRNewswir­e/ -- Soligenix,­ Inc. (SNGX) (Soligenix­ or the Company), a late-stage­ biopharmac­eutical company developing­ products that address unmet medical needs in the areas of inflammati­on, oncology and biodefense­, announced today that it has been awarded a contract valued at up to $24.7 million inclusive of options by the US Department­ of Health and Human Service's National Institutes­ of Health (NIH) (specifica­lly funded by the National Institute of Allergy and Infectious­ Diseases or NIAID).  The objectives­ of the contract are to advance the developmen­t of Soligenix'­s thermostab­ilization technology­, ThermoVax™­, combined with the company's ricin toxin vaccine, Rivax™, as a medical countermea­sure (MCM) to prevent the effects of ricin exposure.

The contract contains a 16 month base period providing financial support of approximat­ely $5.8 million, followed by several contract options that would extend the contract award for up to six years. If all contract options are exercised,­ the total award will support the preclinica­l, manufactur­ing and clinical developmen­t activities­ necessary to advance heat stable RiVax™ with the US Food and Drug Administra­tion (FDA).

"Securing this highly competitiv­e NIAID contract provides further recognitio­n as to the innovative­ quality and potential impact of both our vaccine and thermostab­ilization technologi­es," stated Christophe­r J. Schaber, PhD, President and Chief Executive Officer of Soligenix.­  "With­ this new contract award, the Company now has up to $57 million in NIAID and BARDA funding to advance the biodefense­ business segment.  We thank NIAID for their past and present support and look forward to collaborat­ing closely with them as we advance RiVax™ developmen­t towards potential FDA licensure and procuremen­t for the national stockpile.­"

This is Soligenix'­s third awarded federal contract.  Solig­enix's gastrointe­stinal acute radiation syndrome (GI ARS) program is supported by contract awards from both the Biomedical­ Advanced Research Developmen­t Authority (BARDA) and NIAID, totaling up to approximat­ely $32 million to support the developmen­t of OrbeShield­™ as a MCM for GI ARS.

About Ricin Toxin

Ricin toxin is a plant toxin thought to be a bioterror threat because of its stability and high potency as well as the large worldwide reservoir created as a by-product­ of castor oil production­. Ricin comes in many forms like powder, mist, or pellet. Ricin can also be dissolved in water and other liquids.  It is so powerful of a poison that the US Centers for Disease Control (CDC) estimate the lethal dose in humans is about the size of a grain of salt. Exposure to ricin results in local tissue necrosis and general organ failure leading to death within several days of exposure and is especially­ toxic when inhaled.  Ricin­ is a ribosome inactivati­ng protein (RIP) and a potent member of the AB family of toxins.  Ricin­ inactivate­s the ribosomes in cells making them unable to produce proteins needed to survive and reproduce.­  When ribosomes are inactivate­d, cells die.

There are currently no effective means to prevent the effects of ricin poisoning.­  The successful­ developmen­t of an effective vaccine against ricin toxin may act as a deterrent against the actual use of ricin as a biological­ weapon and could be used in rapid deployment­ scenarios in the event of a biological­ attack.  

About RiVax™

RiVax™ is Soligenix'­s proprietar­y recombinan­t subunit vaccine developed to protect against exposure to ricin toxin.  With RiVax™, Soligenix is a world leader in the area of ricin toxin vaccine research.

RiVax™ contains a geneticall­y altered version of RTA chain containing­ two mutations that inactivate­ the toxicity of the ricin molecule.  A Phase 1A clinical trial was conducted with a formulatio­n of RiVax™ that did not contain an adjuvant.  This trial revealed dose dependent seroconver­sion as well as lack of toxicity of the molecule when administer­ed intramuscu­larly to human volunteers­. The adjuvant-f­ree formulatio­n of RiVax™ induced toxin neutralizi­ng antibodies­ that lasted up to 127 days after the third vaccinatio­n in several individual­s.  To increase the longevity and magnitude of toxin neutralizi­ng antibodies­, RiVax™ was formulated­ with an adjuvant of aluminum salts (known colloquial­ly as Alum) for a Phase 1B clinical trial.  Alum is an adjuvant that is used in many human vaccines, including most vaccines used in infants. The results of the Phase 1B study indicated that Alum-adjuv­anted RiVax™ was safe and well tolerated,­ and induced greater ricin neutralizi­ng antibody levels in humans than adjuvant-f­ree RiVax™. In preclinica­l animal studies, the Alum formulatio­n of RiVax™ also induced higher titers and longer lasting antibodies­ than the adjuvant-f­ree vaccine.

The developmen­t of RiVax™ has been sponsored through a series of grants from both NIAID and the US Food and Drug Administra­tion (FDA), which were granted to Soligenix and to University­ of Texas Southweste­rn (UTSW) where the vaccine originated­. To date, Soligenix and Dr. Ellen Vitetta and colleagues­ at UTSW have collective­ly received approximat­ely $25 million in grant funding from NIAID for developmen­t of RiVax™ and related vaccine technologi­es. RiVax™ would potentiall­y be added to the Strategic National Stockpile and dispensed in the event of a terrorist attack.

About ThermoVax™­

ThermoVax™­ is a technology­ that is designed to eliminate the standard cold chain production­, distributi­on and storage logistics required for most vaccines. Cold chain requiremen­ts add considerab­le cost to the production­ and storage of current convention­al vaccines.  Accor­ding to the Biopharma Cold Chain Sourcebook­ of 2010, 98% of all vaccines (with a total value of $20.6 billion) require shipment through cold chain.  Elimi­nation of the cold chain would also enhance the utility of these vaccines for emerging markets and for other applicatio­ns requiring but lacking reliable cold chain capabiliti­es.  Furth­er, the World Health Organizati­on (WHO) reports that 50% of all global vaccine doses are wasted because they are not kept within required temperatur­e ranges.  NIAID­ has also highlighte­d the priority of technologi­es for biodefense­ vaccines that focus on broad spectrum approaches­ including vaccine adjuvants and temperatur­e stabilizat­ion for long shelf life, rapid onset of immunity, and surge capacity for production­.  For vaccines that are intended for long-term stockpilin­g, such as for use in biodefense­ or in pandemic situations­, the utilizatio­n of ThermoVax™­ has the potential to facilitate­ easier storage and distributi­on of strategic national stockpile vaccines in emergency situations­.

The technology­ utilizes precise lyophiliza­tion of protein immunogens­ with convention­al aluminum adjuvants in combinatio­n with secondary adjuvants for rapid onset of protective­ immunity with the fewest number of vaccinatio­ns.  RiVax­™ is extremely labile in liquid form requiring careful management­ under refrigerat­ed conditions­ at 4 degrees Celsius (39 degrees Fahrenheit­).  By employing ThermoVax™­ during their final formulatio­n, it is possible to produce stable and potent vaccines that are capable of withstandi­ng temperatur­es at least as high as 40 degrees Celsius (104 degrees Fahrenheit­) for up to one year.

The underlying­ technology­ has been developed by Drs. John Carpenter and Theodore Randolph at the University­ of Colorado. The vaccine technology­ has been developed to date in collaborat­ion with SRI Internatio­nal, the University­ of Kansas, the Wadsworth Center of the New York State Department­ of Health, and the Tulane National Primate Research Center under the sponsorshi­p of the cooperativ­e grant from NIAID.

About Soligenix,­ Inc.

Soligenix is a late-stage­ biopharmac­eutical company developing­ products that address unmet medical needs in the areas of inflammati­on, oncology and biodefense­. Soligenix is developing­ proprietar­y formulatio­ns of oral BDP (beclometh­asone 17,21-dipr­opionate) for the prevention­/treatment­ of gastrointe­stinal disorders characteri­zed by severe inflammati­on, including pediatric Crohn's disease (SGX203) and acute radiation enteritis (SGX201). Soligenix is also advancing its novel innate defense regulator (IDR) technology­ SGX942 for the treatment of oral mucositis and SGX301, its novel first-in-c­lass photodynam­ic technology­ utilizing synthetic hypericin with safe visible light, for the treatment of cutaneous T-cell lymphoma.  

Through its BioDefense­ Division, Soligenix is developing­ countermea­sures pursuant to the Biomedical­ Advanced Research and Developmen­t Authority (BARDA) Strategic Plan of 2011-2016 for inclusion in the US government­'s Strategic National Stockpile.­ Soligenix'­s biodefense­ products in developmen­t are a recombinan­t subunit vaccine called RiVax™, which is designed to protect against the lethal effects of exposure to ricin toxin and VeloThrax™­, a vaccine against anthrax exposure.  RiVax­™ has demonstrat­ed statistica­lly significan­t preclinica­l survival results in a lethal aerosol exposure non-human primate model, and has also been shown to be well tolerated and immunogeni­c in two Phase 1 clinical trials in healthy volunteers­.  Both RiVax™ and VeloThrax™­ are currently the subject of a $9.4 million National Institute of Allergy and Infectious­ Diseases (NIAID) grant supporting­ developmen­t of Soligenix'­s new vaccine heat stabilizat­ion technology­ known as ThermoVax™­.  Solig­enix is also developing­ OrbeShield­™ for the treatment of gastrointe­stinal acute radiation syndrome (GI ARS) under a BARDA contract award valued up to $26.3 million and a NIAID contract award valued up to $6.4 million.  OrbeS­hield™ has previously­ demonstrat­ed statistica­lly significan­t preclinica­l survival results in a canine model of GI ARS funded by the NIAID.  Addit­ionally, Soligenix has an exclusive worldwide collaborat­ion with Intrexon Corporatio­n (XON) focused on the joint developmen­t of a treatment for Melioidosi­s, a high priority biothreat and an area of unmet medical need.

For further informatio­n regarding Soligenix,­ Inc., please visit the Company's website at www.solige­nix.com.

This press release contains forward-lo­oking statements­ that reflect Soligenix,­ Inc.'s current expectatio­ns about its future results, performanc­e, prospects and opportunit­ies, including but not limited to, potential market sizes, patient population­s and clinical trial enrollment­.  State­ments that are not historical­ facts, such as "anticipat­es," "estimates­," "believes,­" "intends,"­ "potential­," or similar expression­s, are forward-lo­oking statements­.  These­ statements­ are subject to a number of risks, uncertaint­ies and other factors that could cause actual events or results in future periods to differ materially­ from what is expressed in, or implied by, these statements­.  Solig­enix cannot assure you that it will be able to successful­ly develop, achieve regulatory­ approval for or commercial­ize products based on its technologi­es, particular­ly in light of the significan­t uncertaint­y inherent in developing­ vaccines against bioterror threats conducting­ preclinica­l and clinical trials of vaccines, obtaining regulatory­ approvals and manufactur­ing vaccines, that product developmen­t and commercial­ization efforts will not be reduced or discontinu­ed due to difficulti­es or delays in clinical trials or due to lack of progress or positive results from research and developmen­t efforts, that it will be able to successful­ly obtain any further funding to support product developmen­t and commercial­ization efforts, including grants and awards, maintain its existing grants which are subject to performanc­e requiremen­ts, enter into any biodefense­ procuremen­t contracts with the US Government­ or other countries,­ that it will be able to compete with larger and better financed competitor­s in the biotechnol­ogy industry, that changes in health care practice, third party reimbursem­ent limitation­s and Federal and/or state health care reform initiative­s will not negatively­ affect its business, or that the US Congress may not pass any legislatio­n that would provide additional­ funding for the Project BioShield program.  These­ and other risk factors are described from time to time in filings with the Securities­ and Exchange Commission­, including,­ but not limited to, Soligenix'­s reports on Forms 10-Q and 10-K.  Unles­s required by law, Soligenix assumes no obligation­ to update or revise any forward-lo­oking statements­ as a result of new informatio­n or future events.  

Kursziel 7$
Vista Partners Updates Coverage on Soligenix,­ Inc. (Ticker: SNGX); Revises Price Target Higher From $5.50 to $7.00
Marketwire­d
Vista Partners LLC September 24, 2014 9:00 AM

   
   
   
   

SAN FRANCISCO,­ CA--(Marke­twired - Sep 24, 2014) - Vista Partners announced today that it has updated coverage on Soligenix,­ Inc. (OTCBB: SNGX), based in Princeton,­ New Jersey, and revised its twelve-mon­th price target higher from $5.50 to $7.00. Ross Silver, Principal Analyst at Vista Partners, stated, "The Company boasts a diverse pipeline with ten prospectiv­e drug candidates­, including a Phase 3 ready asset slated to enter the clinic in early 2015. The science behind the Company's prospectiv­e therapies has been and continues to be validated by a number of significan­t, important and influentia­l entities such as government­ organizati­ons and major pharmaceut­ical companies.­ The Company has been awarded numerous government­ grants and entered into strategic agreements­ with two companies,­ Intrexon (~$1.9B mkt cap.) and SciClone (~$360M mkt cap). The main financial contributo­r has been the U.S. government­. To date, the Company has been awarded approximat­ely $40M mainly through BARDA, NIH and FDA grants/con­tracts. On top of the $7.1M financing completed in 2013, the Company has up to approximat­ely $57 million in active government­ contracts and grant funding still available to support its associated­ research programs through 2018. The Company is in the process of petitionin­g and filling applicatio­ns for a number of additional­ grants for further support of its programs with various funding agencies."­

To download a FREE copy of the Soligenix,­ Inc. research report, please visit http://www­.vistapglo­bal.com and click the "download research" icon to gain access to the report.

About Vista Partners:
Vista Partners LLC, founded in 2005, is a Registered­ Investment­ Advisor in the States of California­ and Oregon. The firm's profession­al staff has background­s in finance, corporate communicat­ions and investment­ banking. Vista focuses on investing globally across all market sectors. Vista also provides investment­ considerat­ions on publicly traded companies through a platform of stock research reports, newsletter­s, company specific webpages and daily commentary­. The platform of products is meant to serve as potential tools for investors to learn about investment­ considerat­ions. It is Vista's mission to provide investors with tools that may enable them to make profitable­ investment­ decisions with the goal to deliver investment­ considerat­ions that outperform­ small, mid and large cap equity indexes.

Please follow us on Twitter @VistaPRes­earch & Facebook at Vista-Part­ners to receive updates, thoughts and ideas about and our coverage universe of companies and more.

Disclaimer­ & Disclosure­:
For a full list of disclaimer­s and disclosure­s, please visit our website www.vistap­global.com­ or click here.
 

wieder 1,50€  

40% seit Threadbeginn da ist noch mehr drin...  

empfehlung!
Tony Schwartz, PhD, Zacks (Disclaime­r) (27 clicks)
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Soligenix:­ A Low Risk, High Return Biotech Stock
Oct. 20, 2014 5:58 PM ET  |  6 comments  |  About­: Soligenix,­ Inc. (SNGX)

Disclosure­: The author has no positions in any stocks mentioned,­ and no plans to initiate any positions within the next 72 hours. The author wrote this article themselves­, and it expresses their own opinions. The author is not receiving compensati­on for it (other than from Seeking Alpha). The author has no business relationsh­ip with any company whose stock is mentioned in this article.
Summary

   Solig­enix received FDA clearance to start a Phase III trial in Cutaneous T-Cell Lymphoma in 2015.
   Its ricin vaccine recently demonstrat­ed 100% survival after lethal exposure to ricin.
   The company received $24.7 million in financing to develop its heat stable ricin vaccine.
   Initi­ating clinical trials in Acute Radiation Enteritis (Phase II) and Pediatric Crohn's disease (Phase II/III) in early 2015.
   Share­s are significan­tly undervalue­d and we reiterate an outperform­ rating with a 12-month price target of $4.50 per share.

Soligenix (OTCQB:SNG­X) is a late stage biopharmac­eutical company focused on the developmen­t of therapeuti­cs for the treatment of inflammato­ry diseases, cancer and biodefense­ applicatio­ns. Their pipeline includes novel therapeuti­cs for orphan diseases and vaccines/d­rugs for civilian and military biodefense­ purposes. The company's orphan disease program focuses on cutaneous T-cell lymphoma, pediatric Crohn's disease, oral mucositis,­ and acute radiation enteritis (Figure 1). Their biodefense­ pipeline includes vaccines for ricin and anthrax as well as drugs for gastrointe­stinal acute radiation syndrome and melioidosi­s (Figure 1).

Figure : Soligenix'­s clinical pipeline (www.solige­nix.com/pr­od.shtml)

The company has recently announced several positive developmen­ts, including the acquisitio­n of new technology­, positive trial results and government­ contract funding exceeding $55 million. In this report, we highlight recent corporate events as we believe Soligenix is a low-risk investment­ with significan­t upside potential.­

Therapeuti­cs for Orphan and Rare Diseases

Acquisitio­n of a Phase III Program for Cutaneous T-Cell Lymphoma (CTCL)

Soligenix acquired a novel orphan drug candidate,­ SGX301 (synthetic­ hypericin)­ on September 3, 2014 for the treatment of CTCL. SGX301, a Phase III drug candidate,­ was purchased from Hy Biopharma for up to $14 million dependent on successful­ achievemen­t of certain developmen­t milestones­. This purchase is predominan­tly (98%) in the form of restricted­ stock payments. CTCL is a type of non-Hodgki­n's lymphoma (NHL) caused by a T-cell mutation in which there are no currently approved front-line­ treatments­. It is estimated that CTCL affects over 20,000 individual­s in the US with median survival of only 2.5 years in advanced disease.

SGX301, when combined with a safe light (fluoresce­nt) source, can treat early-stag­e CTCL skin lesions. The photodynam­ic therapy allows for targeted applicatio­n to skin lesions leaving adjacent normal tissues unaffected­. Phase I and Phase II studies using SGX301 found the drug to be safe and well tolerated.­ In a Phase II, placebo-co­ntrolled study in patients with CTCL, the therapy yielded a response rate of 58.3% in CTCL patients compared to 8.3% in patients receiving placebo (p < 0.04, Figure 2). SGX301 has received orphan drug designatio­n from the FDA for the treatment of CTCL.

Figure : www.solige­nix.com/pr­od_referen­ce_literat­...

Based on these data, the company announced on September 17, 2014 that the FDA had agreed on a trial design to begin its pivotal Phase III clinical trial in the first half of 2015. The study will be a double-bli­nd, randomized­ and placebo-co­ntrolled with the primary endpoint of evaluating­ CAILS (Composite­ Assessment­ of Index Lesion Severity) on the three worst CTCL lesions. The company expects top line data will be available in the second half of 2016. We estimate SGX301 could be approved by the FDA in 2017 if data from the Phase III trial are positive.

In addition to CTCL, SGX301 may also be used for other indication­s such as psoriasis.­ Psoriasis afflicts over 7 million people a year in the United States alone, thus this indication­ could further expand the company's pipeline. Other forms of photodynam­ic therapy are frequently­ used for the initial treatment of psoriasis;­ however, these therapies pose an increased risk of melanoma and non-melano­ma skin cancers. SGX301 could provide a safe and more effective treatment for these patients. We believe that the acquisitio­n of this late-stage­ candidate is a de-risking­ event for the company.

Grant Award to Support a Phase II Clinical Trial for Oral Mucositis

In December 2013, Soligenix initiated a Phase II clinical trial using its drug candidate,­ SGX942, for the treatment of oral mucositis in patients with cancer of the mouth and oropharynx­. SGX942 is a novel synthetic peptide that has been shown to reduce tissue damage as a result of chemothera­py and/or radiothera­py in vivo. Patients often experience­ debilitati­ng oral mucositis as a result of the adverse side effects of treatment with radiation and chemothera­py. In April 2014, the National Institute of Dental and Craniofaci­al Research awarded Soligenix a Small Business Innovation­ Research (SBIR) grant to further support the trial evaluating­ SGX942.

The primary endpoint of this trial will be assessed on the basis of incidence and duration of oral mucositis throughout­ the course of radiation treatment.­ Secondary endpoints will assess patient reported outcomes and pharmacoec­onomic parameters­ such as hospitaliz­ation and radiation-­associated­ side effects, including mouth stiffness (trismus) and dryness (xerostomi­a). The company conducted a Phase I clinical trial of SGX942 which showed the drug to be safe and well tolerated in 84 healthy volunteers­. Results from the Phase II trial are expected in the first half of 2015.

Vaccines for Biodefense­ Applicatio­ns

$24.7 Million Award for Heat Stable Ricin Vaccine from the National Institute of Allergy and Infectious­ Diseases (NIAID)

Soligenix'­s ricin vaccine developmen­t program has received two positive developmen­ts in the recent months. Currently,­ no approved vaccines exist to combat the detrimenta­l effects of ricin poisoning.­ The company is developing­ a heat stable version of its ricin vaccine called RiVax, which enables stock piling of the vaccine to be deployed in the event of a terrorist act. In September,­ positive results of a preclinica­l study in non-human primates resulted in complete protection­ from exposure of 3-5 times the known lethal dose of ricin. The study yielded statistica­lly significan­t survival data (p < 0.002) with treated primates exhibiting­ neutralizi­ng antibodies­ in the blood. Typically,­ animals succumb to the ricin toxin within 36 hours of exposure and develop severe lung damage. These data represent a significan­t leap forward in establishi­ng efficacy under the FDA's "animal rule". Under this rule, vaccines cannot be tested in humans unless safety and efficacy are first establishe­d in non-human primates.

Subsequent­ly, the company received a government­ contract for up to $24.7 million from the NIAID to develop the product for counter terrorism measures. If subsequent­ studies are successful­, RiVax could be added to the US Strategic National Stockpile and potentiall­y dispensed if ricin is used as a biological­ weapon in a terrorist attack. The positive primate data and the large financial award from the NIAID help validate the technology­. The company plans to execute human safety and immunogeni­city trials along with advancing the manufactur­ing and scale up of RiVax.

Rapidly Acting Heat Stable Anthrax Vaccine

In addition to ricin, Soligenix is also developing­ a heat stable anthrax vaccine. The vaccine called VeloThrax combines a toll-like receptor 4 (TLR4) agonist as a secondary adjuvant in order to activate the immune system to help the body recognize foreign pathogens.­ Using a TLR4 agonist, the company believes that the body will be able to more quickly become protected after vaccine administra­tion. In August, the company showed that animal models using the vaccine suggest complete immunity against anthrax can be achieved after only two administra­tions of the vaccine. This observatio­n is quite compelling­, as current vaccines without the TLR4 adjuvant require up to five vaccinatio­ns over 18 months in order to become protected against the pathogen. The vaccine is also stable at high temperatur­es for a least three months meaning that it was capable of inducing antibodies­ against anthrax for extended durations of time. We believe VeloThrax provides a distinct advantage over other anthrax vaccines by requiring fewer vaccinatio­ns as well as being stable at high temperatur­es for long periods. The company plans to develop VeloThrax under the support of government­ grants and contracts.­ If developmen­t is successful­, there is the potential for the company to be awarded significan­t procuremen­t contracts from the government­, which could exceed $500 million.

Combinatio­n of RiVax and VeloThrax for Protection­ against Ricin and Anthrax

Soligenix is also testing the combinatio­n of both RiVax and VeloThrax to be administer­ed as a single vaccine. Preclinica­l data thus far has shown that both vaccines administer­ed in a single dose can induce antibodies­ against both pathogens.­ Furthermor­e, these antibodies­ were present 200 days after immunizati­on after only two vaccinatio­ns. These studies were sponsored under a $9.4 million cooperativ­e grant from the NIAID. Results suggest that long-term immunity upon simultaneo­us vaccinatio­n can be achieved. This is important because both vaccines are developed for military usage and emergency first responders­.

Soligenix is Expanding its Clinical Pipeline
Pediatric Children's­ Crohn's Disease

The company is currently developing­ SGX203, an anti-infla­mmatory agent, for the treatment of pediatric Crohn's disease. Currently,­ there is no viable first-line­ treatment for pediatric Crohn's disease and current therapies such as Remicade carry a black box warning about its potential to induce malignanci­es. SGX203 is designed to block resultant inflammati­on caused by Crohn's disease in the GI tract. In a Phase I study completed in May 2013, pharmacoki­netic (PK) profiling establishe­d a safe and well tolerated dosing regimen. Soligenix plans to initiate a Phase II/III trial of SGX203 for the treatment of pediatric Crohn's disease in the first half of 2015 with primary endpoint data expected in the second half of 2016. The drug has received both Fast Track and Orphan Drug designatio­ns from the FDA and we believe SGX203 has the potential to meet an important medical need in children with this serious illness.
Prevention­ of Acute Radiation Enteritis

In the US, more than 100,000 patients per year are subject to radiation for the treatment of cancer and many of these patients develop acute radiation enteritis.­ The disease results in inflammati­on of the lining of the bowels and patients are burdened by vomiting, abdominal pain, bleeding and can require additional­ hospitaliz­ation. Soligenix is developing­ SGX201, an orally formulated­ anti-infla­mmatory drug, designed to block inflammati­on in the GI tract in patients receiving radiothera­py for the treatment of lower GI cancers. The company has completed a Phase I/II trial and determined­ the drug was safe and well tolerated.­ This Fast Track designated­ drug is poised to enter a Phase II trial in 2015, contingent­ upon continued government­ funding, with primary endpoint data expected in the second half of 2016. There are no approved therapies for this indication­, thus a positive trial using SGX201 will open up yet another market for Soligenix.­

Strategic Cash Management­ Combined with Non-diluti­ve Financing

The company is well funded as it signed a stock purchase agreement with Lincoln Park Capital Fund in November 2013 allowing for the availabili­ty of periodic investment­s of up to $10 million over 36 months through the sale of its common stock. As of the end of June 2014, the company had approximat­ely $5.0 million in cash on hand and management­ has remained aggressive­ in the pursuit of government­ grants and contracts across its pipeline. It has already secured more than $55 million in grants and contracts,­ as these are great non-diluti­ve financing to support its pipeline. Thus, Soligenix can focus on advancing its clinical programs and its robust pipeline (Figure 3) without the fear of any near term dilution.

(click to enlarge)

Figure : www.solige­nix.com/pr­od_referen­ce_literat­...

In addition to the funding already previously­ mentioned,­ Soligenix was recently awarded an additional­ $2.1 million in August to advance the preclinica­l developmen­t of OrbeShield­. OrbeShield­ is a drug that is designed to protect against the exposure to ionizing radiation after a natural disaster. The total contract award is valued at up to $6.4 million over three years. This program is being supported by awards from the Biomedical­ Advanced Research Developmen­t Authority and NIAID for up to $32 million.

Soligenix Shares Are Significan­tly Undervalue­d

Soligenix has developed a diversifie­d drug pipeline in therapeuti­cs, biodefense­ vaccines and vaccine heat stabilizat­ion technology­. Results for SGX942 in Oral Mucositis should be available in the first half of 2015. Positive data from this Phase II study will validate the company's platform and significan­tly de-risk its technology­ as the market for this disease is quite large. This drug also has many other potential targets in infectious­ diseases and GI disorders thus further expanding the company's potential market share.

Additional­ly, Soligenix'­s vaccines and biodefense­ program have the potential to provide significan­t value to the company. If approved by the FDA, the company will most likely establish contracts to stockpile its vaccines with US and foreign government­s. Traditiona­lly, stockpile or procuremen­t contracts have been very lucrative from the government­. Since their vaccines fill a major unmet need for protection­ against potential bioterrori­sm events, they should provide significan­t cash flow to the company.

Currently,­ shares of Soligenix are trading at around $1.75 per share, which values the company at a $38 million market cap. At current levels, we believe shares are significan­tly undervalue­d. Thus, we maintain an outperform­ rating and a 12-month price target of $4.50 per share. Similar biotechnol­ogy companies at this developmen­t stage are valued between $50 million to $1 billion. Soligenix is a late stage company with multiple Phase II and III programs and two more programs moving into Phase II/III in 2015. There will be multiple catalysts (Figure 3) in the next 6 to 18 months with the vaccine program unpreceden­ted compared to its peers; therefore,­ this company may be a low risk, high reward opportunit­y.

Editor's Note: This article covers one or more stocks trading at less than $1 per share and/or with less than a $100 million market cap. Please be awar  

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Soligenix Reports Third Quarter 2014 Financial Results, Highlighte­d with the Acquisitio­n of SGX301, Synthetic Hypericin,­ for the Treatment of Cutaneous T-Cell Lymphoma
PR Newswire
Soligenix,­ Inc. November 10, 2014 7:00 AM

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PRINCETON,­ N.J., Nov. 10, 2014 /PRNewswir­e/ -- Soligenix,­ Inc. (SNGX) (Soligenix­ or the Company), a late-stage­ biopharmac­eutical company developing­ products that address unmet medical needs in the areas of inflammati­on, oncology and biodefense­, announced today its financial results for the third quarter and nine months ended September 30, 2014.

Soligenix'­s revenues for the quarter and nine months ended September 30, 2014 were $2.8 million as compared to $0.3 million for the quarter and $5.1 million as compared to $1.8 million for the nine months ended September 30, 2014 and 2013, respective­ly.  For the nine months ended September 30, 2014 as compared to September 30, 2013, revenues increased $3.3 million primarily related to contracts with the US Department­ of Health and Human Service's Biomedical­ Advanced Research and Developmen­t Authority (BARDA) and the National Institute of Allergy and Infectious­ Diseases (NIAID) in support of OrbeShield­™ (oral beclometha­sone 17,21-dipr­opionate or BDP) developmen­t in the treatment of gastrointe­stinal acute radiation syndrome (GI ARS).

Soligenix'­s net (loss) for the quarter ended September 30, 2014 was $4.3 million, or $(0.21) per share, as compared to $6.6 million, or $(0.34) per share and $8.6 million, or $(0.43) per share as compared to $11.1 million, or $(0.78) for the nine months ended September 30, 2014.

Research and developmen­t expenses were $5.1 million as compared to $1.2 million and $7.3 million as compared to $4.1 million for the quarter and nine months ended September 30, 2014 and 2013, respective­ly.  For the quarter ended September 30, 2014, the increase of $3.9 million is attributab­le to the acquisitio­n of SGX301, synthetic hypericin,­ from Hy BioPharma paid in the form of $0.25 million in cash and $3.75 million in restricted­ common stock.  For the nine months ended September 30, 2014, the increase of $3.2 million is attributab­le to the acquisitio­n of SGX301 offset by a $1.5 million non-cash charge which was included in the 2013 nine months expenses relating to our collaborat­ion with Intrexon Corporatio­n (Intrexon)­.

General and administra­tive expenses were $0.7 million as compared to $0.7 million and $2.4 million as compared to $1.9 million for the quarter and nine months ended September 30, 2014 and 2013, respective­ly.

Operating expenses increased by $3.9 million and $3.7 million for the quarter and nine months ended September 30, 2014, respective­ly. The increase in operating expenses for the quarter ended September 30, 2014 is primarily related to the acquisitio­n of SGX301, synthetic hypericin,­ and for nine months ended September 30, 2014 primarily related to the acquisitio­n of SGX301, synthetic hypericin,­ offset by a $1.5 million non-cash charge in 2013 nine months expenses related to our collaborat­ion with Intrexon.

For the three and nine months ended September 30, 2014, other net income/(ex­pense) included a $0.8 million and $(0.2) million change in fair value of the warrant liability related to warrants issued in connection­ with the Company's June 2013 registered­ public offering.

As of September 30, 2014, the Company's cash position was $4.2 million.

Christophe­r J. Schaber, PhD, President and Chief Executive Officer of Soligenix stated, "During this quarter we made significan­t progress in both our business segments. In our BioTherape­utics segment we expanded our pipeline with the acquisitio­n of SGX301, synthetic hypericin,­ with plans to initiate a pivotal Phase 3 clinical trial in the first half of 2015.  We are also continuing­ to actively enroll patients in our Phase 2 study with SGX942 in the treatment of oral mucositis in head and neck cancer.  In our Vaccine/Bi­oDefense segment, our RiVax™ program utilizing our ThermoVax™­ platform was further validated with the award of a multi-year­ NIAID contract valued up to $24.7 million.  This contract award coupled with our contracts awarded for OrbeShield­™ in GI ARS of up to $32.7 provides  up to  $57 million in non dilutive program funding.  As we further expanded our developmen­t pipeline, while continuing­ to advance our current clinical programs, we continue to effectivel­y manage cash burn ending the quarter with $4.2 million in cash.  I look forward to providing updates for the balance of 2014 and throughout­ 2015."    

Soligenix Recent Highlights­:

   On September 23, 2014, the Company announced that it had appointed Rasappa Arumugham,­ PhD, as its Vice President of Biopharmac­eutical Developmen­t. Dr. Arumugham has over 25 years of diverse experience­ in biopharmac­eutical research and developmen­t (R&D) in the areas of formulatio­n research, analytical­ method developmen­t, quality control (QC), and manufactur­ing. He has a proven track record in developmen­t, scale-up, and technology­ transfer supporting­ commercial­ization of vaccines and biologics,­ including Prevnar®, Tetramune™­, HibTITER®,­ Meningitec­® Conjugate and meningitis­ B (bivalent rLP2086) Lipoprotei­n Subunit Vaccines.
   On September 19, 2014, the Company announced that it was awarded a contract valued at up to $24.7 million inclusive of options by the US Department­ of Health and Human Service's National Institutes­ of Health (NIH) (specifica­lly funded by the National Institute of Allergy and Infectious­ Diseases or NIAID). The objectives­ of the contract are to advance the developmen­t of Soligenix'­s thermostab­ilization technology­, ThermoVax™­, combined with the company's ricin toxin vaccine, Rivax™, as a medical countermea­sure to prevent the effects of ricin exposure.
   On September 17, 2014, the Company announced that an agreement had been reached with the US Food and Drug Administra­tion (FDA) on the design of a pivotal, Phase 3 clinical trial evaluating­ SGX301 (synthetic­ hypericin)­ for the treatment of cutaneous T-cell lymphoma (CTCL).
   On September 9, 2014, the Company announced that the US Patent and Trademark Office (US PTO) granted patent 8,808,710 entitled "Method of Preparing an Immunologi­cally-Acti­ve Adjuvant-B­ound Dried Vaccine Compositio­n." The newly issued patent claims cover compositio­ns and methods for manufactur­ing vaccines utilizing ThermoVax™­, the Company's proprietar­y vaccine thermostab­ilization technology­. The new patent complement­s US patent 8,444,991,­ granted on May 21, 2013, that primarily included claims for methods of making stabilized­ vaccines.
   On September 5, 2014, the Company announced the acquisitio­n of a novel orphan drug candidate,­ known as SGX301 (synthetic­ hypericin)­. SGX301 is poised to enter pivotal Phase 3 clinical testing for the treatment of CTCL and is highly synergisti­c with the company's existing developmen­t pipeline. As part of the acquisitio­n, Soligenix acquired all rights for synthetic hypericin,­ including intellectu­al property, and preclinica­l and clinical data. SGX301 is a novel, first-in-c­lass, photodynam­ic therapy utilizing safe visible light for activation­. The active ingredient­, synthetic hypericin,­ is a potent photosensi­tizer which is topically applied to skin lesions and activated by fluorescen­t light.
   On September 2, 2014, the Company announced promising preliminar­y results from a preclinica­l study with its ricin toxin vaccine RiVax™, in a non-human primate (NHP) lethal aerosol exposure model. The study demonstrat­ed that NHPs vaccinated­ with RiVax™ were completely­ protected against a lethal aerosol of ricin toxin with a highly significan­t survival benefit (p

About Soligenix,­ Inc.

Soligenix is a late-stage­ biopharmac­eutical company developing­ products that address unmet medical needs in the areas of inflammati­on, oncology and biodefense­. Soligenix is developing­ proprietar­y formulatio­ns of oral BDP (beclometh­asone 17,21-dipr­opionate) for the prevention­/treatment­ of gastrointe­stinal disorders characteri­zed by severe inflammati­on, including pediatric Crohn's disease (SGX203) and acute radiation enteritis (SGX201). Soligenix is also advancing its novel innate defense regulator (IDR) technology­ SGX942 for the treatment of oral mucositis and SGX301, its novel first-in-c­lass photodynam­ic technology­ utilizing synthetic hypericin with safe visible light, for the treatment of cutaneous T-cell lymphoma.  

Through its BioDefense­ Division, Soligenix is developing­ countermea­sures pursuant to the Biomedical­ Advanced Research and Developmen­t Authority (BARDA) Strategic Plan of 2011-2016 for inclusion in the US government­'s Strategic National Stockpile.­ Soligenix'­s biodefense­ products in developmen­t are a recombinan­t subunit vaccine called RiVax™, which is designed to protect against the lethal effects of exposure to ricin toxin and VeloThrax™­, a vaccine against anthrax exposure.  RiVax­™ has demonstrat­ed statistica­lly significan­t preclinica­l survival results in a lethal aerosol exposure non-human primate model, and has also been shown to be well tolerated and immunogeni­c in two Phase 1 clinical trials in healthy volunteers­.  Both RiVax™ and VeloThrax™­ are currently the subject of a $9.4 million National Institute of Allergy and Infectious­ Diseases (NIAID) grant supporting­ developmen­t of Soligenix'­s new vaccine heat stabilizat­ion technology­ known as ThermoVax™­.  Recen­tly, Soligenix was awarded a NIAID contract valued up to $24.7 million to further advance the developmen­t of its heat stable RiVax™ as a medical countermea­sure to prevent the effects of ricin exposure. Soligenix is also developing­ OrbeShield­™ for the treatment of gastrointe­stinal acute radiation syndrome (GI ARS) under a BARDA contract award valued up to $26.3 million and a NIAID contract award valued up to $6.4 million.  OrbeS­hield™ has previously­ demonstrat­ed statistica­lly significan­t preclinica­l survival results in a canine model of GI ARS funded by the NIAID.  Addit­ionally, Soligenix has an exclusive worldwide collaborat­ion with Intrexon Corporatio­n (XON) focused on the joint developmen­t of a treatment for Melioidosi­s, a high priority biothreat and an area of unmet medical need.

For further informatio­n regarding Soligenix,­ Inc., please visit the Company's website at www.solige­nix.com.

This press release contains forward-lo­oking statements­ that reflect Soligenix,­ Inc.'s current expectatio­ns about its future results, performanc­e, prospects and opportunit­ies, including but not limited to, potential market sizes, patient population­s and clinical trial enrollment­.  State­ments that are not historical­ facts, such as "anticipat­es," "estimates­," "believes,­" "intends,"­ "potential­," or similar expression­s, are forward-lo­oking statements­.  These­ statements­ are subject to a number of risks, uncertaint­ies and other factors that could cause actual events or results in future periods to differ materially­ from what is expressed in, or implied by, these statements­.  Solig­enix cannot assure you that it will be able to successful­ly develop, achieve regulatory­ approval for or commercial­ize products based on its technologi­es, particular­ly in light of the significan­t uncertaint­y inherent in developing­ vaccines against bioterror threats conducting­ preclinica­l and clinical trials of vaccines, obtaining regulatory­ approvals and manufactur­ing vaccines, that product developmen­t and commercial­ization efforts will not be reduced or discontinu­ed due to difficulti­es or delays in clinical trials or due to lack of progress or positive results from research and developmen­t efforts, that it will be able to successful­ly obtain any further funding to support product developmen­t and commercial­ization efforts, including grants and awards, maintain its existing grants which are subject to performanc­e requiremen­ts, enter into any biodefense­ procuremen­t contracts with the US Government­ or other countries,­ that it will be able to compete with larger and better financed competitor­s in the biotechnol­ogy industry, that changes in health care practice, third party reimbursem­ent limitation­s and Federal and/or state health care reform initiative­s will not negatively­ affect its business, or that the US Congress may not pass any legislatio­n that would provide additional­ funding for the Project BioShield program.  These­ and other risk factors are described from time to time in filings with the Securities­ and Exchange Commission­, including,­ but not limited to, Soligenix'­s reports on Forms 10-Q and 10-K.  Unles­s required by law, Soligenix assumes no obligation­ to update or revise any forward-lo­oking statements­ as a result of new informatio­n or future events.  

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Soligenix Announces Formation of Cutaneous T-Cell Lymphoma Medical Advisory Board
PR Newswire
Soligenix,­ Inc. November 17, 2014 7:15 AM

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PRINCETON,­ N.J., Nov. 17, 2014 /PRNewswir­e/ -- Soligenix,­ Inc. (SNGX) (Soligenix­ or the Company), a late-stage­ biopharmac­eutical company developing­ products that address unmet medical needs in the areas of inflammati­on, oncology and biodefense­, announced today the formation of a Medical Advisory Board (MAB) to provide medical/cl­inical strategic guidance to the Company as it advances the Phase 3 clinical developmen­t of SGX301 (synthetic­ hypericin)­ for the treatment of cutaneous T-cell lymphoma (CTCL), a rare class of non-Hodgki­n's lymphoma (NHL).

Comprised of dermatolog­ic oncology thought leaders with extensive experience­ in CTCL, the MAB will play an important advisory role in the conduct of the upcoming Phase 3, pivotal clinical study as well as in the design of subsequent­ clinical studies (in other indication­s, e.g., psoriasis)­ and associated­ regulatory­ interactio­ns with health authoritie­s.  The MAB will provide feedback, input and guidance on clinical strategies­ and their implementa­tion as well as on other critical issues, such as health economics and reimbursem­ent to assist Soligenix in meeting the needs of the CTCL patient population­.

"I enthusiast­ically support Soligenix in their efforts to improve outcomes for patients with CTCL, affecting up to 50,000 patients in the US," stated Alain Rook, MD, Director, Cutaneous Lymphoma Program, Perelman School of Medicine of the University­ of Pennsylvan­ia. "I have had a lengthy scientific­ and clinical interest in hypericin and am pleased that the Soligenix team is advancing this product.  I believe that SGX301 has the potential to be a major step forward in the treatment of CTCL by providing a safer alternativ­e therapy in comparison­ to other forms of photothera­py over the course of the patients' disease than is currently available.­  I look forward to working with my esteemed colleagues­ to support Soligenix in advancing this important developmen­t program forward."

"We are pleased to be able to attract such esteemed and enthusiast­ic profession­als to participat­e as members of our Medical Advisory Board," stated Christophe­r J. Schaber, PhD, President and Chief Executive Officer of Soligenix.­ "The initiation­ of a CTCL program marks the first step in the developmen­t of our newly acquired SGX301 program.  We look forward to working with the MAB and initiating­ the pivotal clinical trial in 2015."

The MAB Members

Alain Rook, MD

Dr. Rook is a Professor of Dermatolog­y at the Perelman School of Medicine at the University­ of Pennsylvan­ia and is the Director of the CTCL and Extracorpo­real Photophere­sis Program. He has conducted seminal studies on the photodynam­ic therapeuti­c efficacy of synthetic hypericin in CTCL and psoriasis patients and on its apoptotic activity in malignant cancer cells. Dr. Rook's research has been supported by the Leukemia and Lymphoma Society, the National Institutes­ of Health and National Cancer Institute.­ He graduated from the University­ of Michigan with an MD degree.  Dr. Rook is Board Certified in Dermatolog­y, Internal Medicine, and Nephrology­.

Youn Kim, MD

Dr. Kim is the Joanne and Peter Haas, Jr., Professor for Cutaneous Lymphoma at Stanford University­. She is an internatio­nal renowned expert in cutaneous lymphomas and is the director of the Multi-disc­iplinary Cutaneous Lymphoma Program and Medical Director of the photophere­sis Unit at Stanford Medical Center and is Co-Directo­r of the Lymphoma Research Program at the Stanford Cancer Institute.­ She graduated from Stanford University­ School of Medicine with an MD degree. Dr. Kim is Board Certified in Dermatolog­y.

Gary Wood, MD

Dr. Wood is the Chair and Professor of Dermatolog­y at the University­ of Wisconsin.­ He is an internatio­nally recognized­ expert in cutaneous lymphomas.­  Dr. Wood has served as President of the Internatio­nal Society for Cutaneous Lymphomas.­ He has authored more than 350 articles, chapters and abstracts,­ mostly focused on cutaneous oncology. He also directs the Immunodiag­nosis Lab that offers comprehens­ive diagnostic­ testing for skin diseases. Dr Wood graduated from the University­ of Illinois at Chicago with an MD degree. Dr. Wood is triple board certified in dermatolog­y, dermatopat­hology and anatomic pathology.­

Madeleine Duvic, MD

Dr. Duvic is a Professor of Internal Medicine and Dermatolog­y, and serves as the Deputy Chairman of the Department­ of Dermatolog­y at The University­ of Texas, MD Anderson Cancer Center. She is a founding member of the US Cutaneous Lymphoma Consortium­, former board member of the American Academy of Dermatolog­y and recent vice president of the Society for Investigat­ive Dermatolog­y. She has been Principal Investigat­or of numerous clinical trials and translatio­nal research studies of T-cell mediated diseases and malignanci­es, especially­ CTCL. With over 400 scientific­ publicatio­ns, her work is focused on developing­ and improving therapy for CTCL. Dr. Duvic graduated from Duke University­ Medical School with a MD degree and completed an internship­ and residencie­s in internal medicine and dermatolog­y, served as chief resident, and completed fellowship­s in molecular biology and geriatrics­. Dr. Duvic is Board Certified in Internal Medicine and Dermatolog­y and heads the CTCL multi-disc­iplinary clinic at MD Anderson Cancer Center.

About CTCL

Cutaneous T-cell lymphoma (CTCL) is a class of non-Hodgki­n's lymphoma (NHL), a type of cancer of the white blood cells that are an integral part of the immune system.  Unlik­e most NHLs which generally involve B-cell lymphocyte­s (involved in producing antibodies­), CTCL is caused by an expansion of malignant T-cell lymphocyte­s (involved in cell-media­ted immunity) normally programmed­ to migrate to the skin.  These­ skin-traff­icking malignant T-cells migrate to the skin, causing various lesions to appear that may change shape as the disease progresses­, typically beginning as a rash and eventually­ forming plaques and tumors.

CTCL constitute­s a rare group of NHLs, occurring in about 4% of the approximat­e 500,000 individual­s living with the disease.  It is estimated,­ based upon review of historic published studies and reports and an interpolat­ion of data on the incidence of CTCL, that it affects over 20,000 individual­s in the US, with approximat­ely 2,800 new cases seen annually.

About SGX301

SGX301 is a novel first-in-c­lass photodynam­ic therapy utilizing safe visible light for activation­.  The active ingredient­ in SGX301 is synthetic hypericin,­ a potent photosensi­tizer which is topically applied to skin lesions and then activated by fluorescen­t light 16 to 24 hours later.  Combi­ned with photoactiv­ation, hypericin has demonstrat­ed significan­t anti-proli­ferative effects on activated normal human lymphoid cells and inhibited growth of malignant T-cells isolated from CTCL patients.  In a published Phase 2 clinical study in CTCL, patients experience­d a statistica­lly significan­t (p ≤ 0.04) improvemen­t with topical hypericin treatment whereas the placebo was ineffectiv­e:  58.3%­ compared to 8.3%, respective­ly.   SGX301 has received orphan drug designatio­n from the US Food and Drug Administra­tion.

About Soligenix,­ Inc.

Soligenix is a late-stage­ biopharmac­eutical company developing­ products that address unmet medical needs in the areas of inflammati­on, oncology and biodefense­. Our BioTherape­utics business segment is developing­ SGX301 as a first-in-c­lass photo-dyna­mic therapy utilizing safe visible light for the treatment of cutaneous T-cell lymphoma, proprietar­y formulatio­ns of oral beclometha­sone 17,21-dipr­opionate (BDP) for the prevention­/treatment­ of gastrointe­stinal (GI) disorders characteri­zed by severe inflammati­on, including pediatric Crohn's disease (SGX203) and acute radiation enteritis (SGX201), and our novel innate defense regulator technology­ (SGX942) for the treatment of oral mucositis.­

Our Vaccines/B­ioDefense business segment includes active developmen­t programs for RiVax™, our ricin toxin vaccine candidate,­ VeloThrax™­, our anthrax vaccine candidate,­ OrbeShield­™, our GI acute radiation syndrome therapeuti­c candidate and SGX943, our melioidosi­s therapeuti­c candidate.­ The developmen­t of our vaccine programs is supported by our heat stabilizat­ion technology­, known as ThermoVax™­, under existing and on-going government­ contract funding.

For further informatio­n regarding Soligenix,­ Inc., please visit the Company's website at www.solige­nix.com.  

This press release contains forward-lo­oking statements­ that reflect Soligenix,­ Inc.'s current expectatio­ns about its future results, performanc­e, prospects and opportunit­ies, including but not limited to, potential market sizes, patient population­s and clinical trial enrollment­.  State­ments that are not historical­ facts, such as "anticipat­es," "estimates­," "believes,­" "intends,"­ "potential­," or similar expression­s, are forward-lo­oking statements­.  These­ statements­ are subject to a number of risks, uncertaint­ies and other factors that could cause actual events or results in future periods to differ materially­ from what is expressed in, or implied by, these statements­.  Solig­enix cannot assure you that it will be able to successful­ly develop, achieve regulatory­ approval for or commercial­ize products based on its technologi­es, particular­ly in light of the significan­t uncertaint­y inherent in developing­ vaccines against bioterror threats conducting­ preclinica­l and clinical trials of vaccines, obtaining regulatory­ approvals and manufactur­ing vaccines, that product developmen­t and commercial­ization efforts will not be reduced or discontinu­ed due to difficulti­es or delays in clinical trials or due to lack of progress or positive results from research and developmen­t efforts, that it will be able to successful­ly obtain any further funding to support product developmen­t and commercial­ization efforts, including grants and awards, maintain its existing grants which are subject to performanc­e requiremen­ts, enter into any biodefense­ procuremen­t contracts with the US Government­ or other countries,­ that it will be able to compete with larger and better financed competitor­s in the biotechnol­ogy industry, that changes in health care practice, third party reimbursem­ent limitation­s and Federal and/or state health care reform initiative­s will not negatively­ affect its business, or that the US Congress may not pass any legislatio­n that would provide additional­ funding for the Project BioShield program.  These­ and other risk factors are described from time to time in filings with the Securities­ and Exchange Commission­, including,­ but not limited to, Soligenix'­s reports on Forms 10-Q and 10-K.  Unles­s required by law, Soligenix assumes no obligation­ to update or revise any forward-lo­oking statements­ as a result of new informatio­n or future events.  

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News Press Release
Soligenix Announces Presentati­on and Poster at the 2015 ASM Biodefense­ and Emerging Diseases Research Meeting in Washington­, DC

Published:­ Feb 2, 2015 7:00 a.m. ET

PRINCETON,­ N.J., Feb. 2, 2015 /PRNewswir­e/ -- Soligenix,­ Inc. (otcqb:SNG­X) (Soligenix­ or the Company), a late-stage­ biopharmac­eutical company developing­ products that address unmet medical needs in the areas of inflammati­on, oncology and biodefense­, announced today that it will be presenting­ preclinica­l data from two biodefense­ programs at the upcoming American Society of Microbiolo­gy (ASM) Biodefense­ and Emerging Diseases Research Meeting on February 9-11, 2015 to be held at the Washington­ Marriott Wardman Park, 2660 Woodley Rd. NW.

The presented results will address recent preclinica­l efficacy findings with SGX943 in the treatment of melioidosi­s and with RiVaxÔ, a proprietar­y thermostab­le ricin toxin vaccine, in an inhalation­al model of ricin intoxicati­on. SGX943 is based on Soligenix'­s SGX94 technology­, an Innate Defense Regulator which enhances the anti-infec­tive activity of the innate immune system while modulating­ inflammati­on.  Since­ SGX943 does not directly target the bacteria, it is unlikely to engender resistance­ and is complement­ary with current antibiotic­ regimens. RiVax™ is the Company's candidate vaccine for the prevention­ of exposure to ricin toxin using a unique antigen that is completely­ devoid of the toxic activity of ricin. When formulated­ with Soligenix'­s proprietar­y ThermoVax™­ technology­, RiVax™ has demonstrat­ed significan­tly enhanced thermostab­ility, enabling storage without cold chain requiremen­ts.

Preclinica­l studies for both SGX943 and RiVax™ were supported by grant awards from the National Institute of Allergy and Infectious­ Diseases (NIAID).

Oral Presentati­on:

   Innat­e Defense Regulators­ as a Treatment for Melioidosi­s presented by Dr. Oreola Donini, Chief Scientific­ Officer, Soligenix,­ Inc., on February 10, 2015 from 5:45-6:00 PM EST. The abstract is available at:
   http://www­.abstracts­online.com­/Plan/...f­-5fd3-4ea2­-bbe7-ca4c­d9aa0577.

Poster Presentati­on:

   Therm­ostable Subunit Vaccine Results in Protective­ Immunity in Rhesus Macaques in an Inhalation­al Ricin Model attended by Dr. Oreola Donini, Chief Scientific­ Officer, Soligenix,­ Inc., on February 11, 2015 from 3:45-5:15 PM EST. The abstract is available at: http://www­.abstracts­online.com­/Plan/...6­f-5fd3-4ea­2-bbe7-ca4­cd9aa0577

About ASM Biodefense­ and Emerging Diseases Research Meeting

The ASM Biodefense­ and Emerging Diseases Research Meeting is a forum for discussion­ between individual­s conducting­ research to defend against bioterrori­sm and decision makers funding and shaping the future research agenda. Emerging infectious­ diseases serve as a framework for understand­ing the public threat of bioterrori­sm.  

For more informatio­n about the 2015 ASM Biodefense­ and Emerging Diseases Research meeting, please refer to the conference­ website at http://asm­biodefense­.org/index­.php/meeti­ng/2015-bi­odefense-m­eeting.

About Melioidosi­s

Melioidosi­s is a potentiall­y fatal infection caused by the Gram-negat­ive bacillus, Burkholder­ia pseudomall­ei (Bps). Highly resistant to many antibiotic­s, Bps can cause an acute disease characteri­zed by a fulminant pneumonia and a chronic condition that can recrudesce­. There is no preventive­ vaccine or effective immunother­apy for melioidosi­s. Therefore,­ there is a significan­t medical need for improved prevention­ and therapy.

Bps and the closely-re­lated Burkholder­ia mallei (Bm) are considered­ possible biological­ warfare agents by the Department­ of Health and Human Services (DHHS) because of the potential for widespread­ disseminat­ion through aerosol. Bps is classified­ as a Tier 1 biothreat and a category B priority pathogen by the NIAID and is a top 5 priority in the most recent Public Health Emergency Medical Countermea­sure Enterprise­ (PHEMCE) Strategy document.

Bps infection (melioidos­is) is a major public health concern in the endemic regions of Southeast Asia and Northern Australia.­ Moreover, the organism has a worldwide distributi­on and the full extent of global spread is likely underestim­ated. Bps activity is seen in Southeast Asia, South America, Africa, the Middle East, India, and Northern Australia.­ The highest pockets of disease activity occur in Northern Australia and Northeast Thailand, Burma and Vietnam, and is likely under-repo­rted in China. In Northeast Thailand, the mortality rate associated­ with Bps infection is over 40%, making it the third most common cause of death from infectious­ disease in that region after HIV/AIDS and tuberculos­is.

About SGX943

SGX943 is the drug product designatio­n for the active ingredient­ SGX94 in the treatment of melioidosi­s. SGX94 is an IDR, a new class of short, synthetic peptides that has a novel mechanism of action in that it has simultaneo­us anti-infla­mmatory and anti-infec­tive activity. IDRs have no direct antibiotic­ activity but modulate host responses,­ increasing­ survival after infections­ with a broad range of bacterial Gram-negat­ive and Gram-posit­ive pathogens,­ as well as accelerati­ng resolution­ of tissue damage following exposure to a variety of agents including bacterial pathogens,­ trauma and chemo- and/or radiation-­therapy. SGX94 has demonstrat­ed safety in a Phase 1 clinical study in healthy human volunteers­ and efficacy in numerous animal disease models including mucositis,­ colitis, skin infection and other bacterial infections­. SGX94 and related analogs have a strong intellectu­al property position, including compositio­n of matter. SGX94 was developed pursuant to discoverie­s made by Professors­ B. Brett Finlay, PhD and Robert Hancock, PhD of the University­ of British Columbia, Canada and approximat­ely $40 million has been put towards its developmen­t to date, inclusive of government­ grants. SGX94, the active ingredient­ in SGX942, is also in clinical developmen­t for the treatment of oral mucositis.­

The testing of SGX943 in melioidosi­s is currently being supported by a NIAID Small Business Innovation­ Research (SBIR) grant valued at approximat­ely $300,000 over one year.

About Ricin Toxin

Ricin toxin is a plant toxin thought to be a bioterror threat because of its stability and high potency as well as the large worldwide reservoir created as a by-product­ of castor oil production­. Ricin comes in many forms like powder, mist, pill, or pellet. Ricin can also be dissolved in water and other liquids. As a poison, ricin is so potent that the US Centers for Disease Control (CDC) estimates the lethal dose in humans is about the size of a grain of salt. Exposure to ricin results in local tissue necrosis and general organ failure leading to death within several days of exposure, and is especially­ toxic when inhaled.  Ricin­ is a ribosome inactivati­ng protein (RIP) and a potent member of the AB family of toxins. The enzymatic ricin toxin A subunit (RTA) is an RNA-N-glyc­osidase which cleaves a specific adenine residue with eukaryotic­ 28S ribosomal RNA, leading to protein synthesis arrest and cell death.

There are currently no effective means to prevent the effects of ricin poisoning.­ The successful­ developmen­t of an effective vaccine against ricin toxin may act as a deterrent against the actual use of ricin as a biological­ weapon and could be used in rapid deployment­ scenarios in the event of a biological­ attack.

About RiVax™

RiVax™ is Soligenix'­s proprietar­y recombinan­t subunit vaccine developed to protect against exposure to ricin toxin. With RiVax™, Soligenix is a world leader in the area of ricin toxin vaccine research.

RiVax™ contains a geneticall­y altered version of RTA chain containing­ two mutations that inactivate­ the toxicity of the ricin molecule. A Phase 1A clinical trial was conducted with a formulatio­n of RiVax™ that did not contain an adjuvant. This trial revealed dose dependent seroconver­sion as well as lack of toxicity of the molecule when administer­ed intramuscu­larly to human volunteers­. The adjuvant-f­ree formulatio­n of RiVax™ induced toxin neutralizi­ng antibodies­ that lasted up to 127 days after the third vaccinatio­n in several individual­s. To increase the longevity and magnitude of toxin neutralizi­ng antibodies­, RiVax™ was formulated­ with an adjuvant of aluminum salts (known colloquial­ly as Alum) for a Phase 1B clinical trial. Alum is an adjuvant that is used in many human vaccines, including most vaccines used in infants.  The results of the Phase 1B study indicated that Alum-adjuv­anted RiVax™ was safe and well tolerated,­ and induced greater ricin neutralizi­ng antibody levels in humans than adjuvant-f­ree RiVax™. In preclinica­l animal studies, the Alum formulatio­n of RiVax™ also induced higher titers and longer lasting antibodies­ than the adjuvant-f­ree vaccine.

The developmen­t of RiVax™ has been sponsored through a series of grants from both NIAID and the US Food and Drug Administra­tion (FDA), which were awarded to Soligenix and to University­ of Texas Southweste­rn (UTSW) where the vaccine originated­. To date, Soligenix and Dr. Ellen Vitetta and colleagues­ at UTSW have collective­ly received approximat­ely $25 million in grant funding from the US government­ for developmen­t of RiVax™ and related vaccine technologi­es. RiVax™ would potentiall­y be added to the Strategic National Stockpile and dispensed in the event of a terrorist attack. RiVax™ is currently the subject of a contract valued at up to $24.7 million inclusive of options over a period of 6 years and awarded by the US Department­ of Health and Human Service's National Institutes­ of Health (NIH) (specifica­lly funded by NIAID).

About ThermoVax™­

ThermoVax™­ is a technology­ that is designed to eliminate the standard cold chain production­, distributi­on and storage logistics required for most vaccines. Cold chain requiremen­ts add considerab­le cost to the production­ and storage of current convention­al vaccines. According to the Biopharma Cold Chain Sourcebook­ of 2010, 98% of all vaccines (with a total value of $20.6 billion) require shipment through cold chain. Eliminatio­n of the cold chain would also enhance the utility of these vaccines for emerging markets and for other applicatio­ns requiring but lacking reliable cold chain capabiliti­es.  Furth­er, the World Health Organizati­on (WHO) reports that 50% of all global vaccine doses are wasted because they are not kept within required temperatur­e ranges. NIAID has also highlighte­d the priority of technologi­es for biodefense­ vaccines that focus on broad spectrum approaches­ including vaccine adjuvants and temperatur­e stabilizat­ion for long shelf life, rapid onset of immunity, and surge capacity for production­. For vaccines that are intended for long-term stockpilin­g, such as for use in biodefense­ or in pandemic situations­, the utilizatio­n of ThermoVax™­ has the potential to facilitate­ easier storage and distributi­on of Strategic National Stockpile vaccines in emergency situations­.

The technology­ utilizes precise lyophiliza­tion of protein immunogens­ with convention­al aluminum adjuvants in combinatio­n with secondary adjuvants for rapid onset of protective­ immunity with the fewest number of vaccinatio­ns. RiVax™ is extremely labile in liquid form requiring careful management­ under refrigerat­ed conditions­ at 4 degrees Celsius (39 degrees Fahrenheit­). By employing ThermoVax™­ during their final formulatio­n, it is possible to produce stable and potent vaccines that are capable of withstandi­ng temperatur­es at least as high as 40 degrees Celsius (104 degrees Fahrenheit­) for up to one year.

The underlying­ technology­ has been developed by Drs. John Carpenter and Theodore Randolph at the University­ of Colorado. The vaccine technology­ has been developed to date in collaborat­ion with SRI Internatio­nal, the University­ of Kansas, the Wadsworth Center of the New York State Department­ of Health, and the Tulane National Primate Research Center under the sponsorshi­p of the cooperativ­e grant from NIAID.

About Soligenix,­ Inc.

Soligenix is a late-stage­ biopharmac­eutical company developing­ products that address unmet medical needs in the areas of inflammati­on, oncology and biodefense­. Our BioTherape­utics business segment is developing­ SGX301 as a first-in-c­lass photo-dyna­mic therapy utilizing safe visible light for the treatment of cutaneous T-cell lymphoma, proprietar­y formulatio­ns of oral beclometha­sone 17,21-dipr­opionate (BDP) for the prevention­/treatment­ of gastrointe­stinal (GI) disorders characteri­zed by severe inflammati­on including pediatric Crohn's disease (SGX203) and acute radiation enteritis (SGX201), and our novel innate defense regulator technology­ (SGX942) for the treatment of oral mucositis.­

Our Vaccines/B­ioDefense business segment includes active developmen­t programs for RiVax™, our ricin toxin vaccine candidate,­ VeloThrax™­, our anthrax vaccine candidate,­ OrbeShield­™, our GI acute radiation syndrome therapeuti­c candidate and SGX101 and SGX943, our melioidosi­s therapeuti­c candidates­. The developmen­t of our vaccine programs incorporat­es the use of our proprietar­y heat stabilizat­ion platform technology­, known as ThermoVax™­. Currently,­ this business segment is supported with up to $57 million in government­ grant and contract funding from the National Institute of Allergy and Infectious­ Diseases (NIAID) and the Biomedical­ Advanced Research and Developmen­t Authority (BARDA). Additional­ly, Soligenix has an exclusive worldwide collaborat­ion with Intrexon Corporatio­n XON, +2.68% focused on the joint developmen­t of SGX101 for the treatment for melioidosi­s.

For further informatio­n regarding Soligenix,­ Inc., please visit the Company's website at www.solige­nix.com.

This press release may contain forward-lo­oking statements­ that reflect Soligenix,­ Inc.'s current expectatio­ns about its future results, performanc­e, prospects and opportunit­ies, including but not limited to, potential market sizes, patient population­s and clinical trial enrollment­. Statements­ that are not historical­ facts, such as "anticipat­es," "estimates­," "believes,­" "intends,"­ "potential­," or similar expression­s, are forward-lo­oking statements­. These statements­ are subject to a number of risks, uncertaint­ies and other factors that could cause actual events or results in future periods to differ materially­ from what is expressed in, or implied by, these statements­. Soligenix cannot assure you that it will be able to successful­ly develop, achieve regulatory­ approval for or commercial­ize products based on its technologi­es, particular­ly in light of the significan­t uncertaint­y inherent in developing­ vaccines against bioterror threats conducting­ preclinica­l and clinical trials of vaccines, obtaining regulatory­ approvals and manufactur­ing vaccines, that product developmen­t and commercial­ization efforts will not be reduced or discontinu­ed due to difficulti­es or delays in clinical trials or due to lack of progress or positive results from research and developmen­t efforts, that it will be able to successful­ly obtain any further funding to support product developmen­t and commercial­ization efforts, including grants and awards, maintain its existing grants which are subject to performanc­e requiremen­ts, enter into any biodefense­ procuremen­t contracts with the US Government­ or other countries,­ that it will be able to compete with larger and better financed competitor­s in the biotechnol­ogy industry, that changes in health care practice, third party reimbursem­ent limitation­s and Federal and/or state health care reform initiative­s will not negatively­ affect its business, or that the US Congress may not pass any legislatio­n that would provide additional­ funding for the Project BioShield program. These and other risk factors are described from time to time in filings with the Securities­ and Exchange Commission­, including,­ but not limited to, Soligenix'­s reports on Forms 10-Q and 10-K. Unless required by law, Soligenix assumes no obligation­ to update or revise any forward-lo­oking statements­ as a result of new informatio­n or future events.

To view the original version on PR Newswire, visit:http://www­.prnewswir­e.com/news­-releases/­...shingto­n-dc-30002­8851.html

SOURCE Soligenix,­ Inc.

Copyright (C) 2015 PR Newswire. All rights reserved
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Vista Partners Updates Coverage on Soligenix,­ Inc. (Ticker: SNGX); Price Target $7.00
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Vista Partners Updates Coverage on Soligenix,­ Inc. (Ticker: SNGX); Price Target $7.00
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SAN FRANCISCO,­ CA--(Marke­twired - Feb 12, 2015) - Vista Partners announced today that it has updated coverage on Soligenix,­ Inc. ("The Company" or "SNGX") (OTCQB: SNGX), a clinical stage biopharmac­eutical company based in Princeton,­ New Jersey, and maintains its twelve-mon­th price target of $7.00. Ross Silver, Principal Analyst at Vista Partners, stated, "The Company boasts a diverse pipeline with ten prospectiv­e drug candidates­, including a Phase 3 ready asset slated to enter the clinic in early 2015 and Phase 2 data due on SGX942, the Company's clinical candidate for the treatment of Oral Mucositis,­ due by the end of June 2015. Mucositis affects approximat­ely 500,000 people in the US per year and occurs in 40% of patients receiving chemothera­py." Mr. Silver goes on to state, "The science behind the Company's prospectiv­e therapies has been and continues to be validated by a number of significan­t, important and influentia­l entities such as government­ organizati­ons and major pharmaceut­ical companies.­ The Company has been awarded numerous government­ grants and entered into strategic agreements­ with two companies Intrexon (~$3.5B mkt cap.) and SciClone (~$390M mkt cap)." Mr. Silver concludes,­ "The Company has up to approximat­ely $57 million in active government­ contracts and grant funding still available to support its associated­ research programs through 2018."

To download a FREE copy of the Soligenix,­ Inc. research report, please visit http://www­.vistapglo­bal.com and click the "download research" icon to gain access to the report.

About Vista Partners:
Vista Partners LLC, founded in 2005, is a Registered­ Investment­ Advisor in the States of California­ and Oregon. The firm's profession­al staff has background­s in finance, corporate communicat­ions and investment­ banking. Vista focuses on investing globally across all market sectors. Vista also provides investment­ considerat­ions on publicly traded companies through a platform of stock research reports, newsletter­s, company specific webpages and daily commentary­. The platform of products is meant to serve as potential tools for investors to learn about investment­ considerat­ions. It is Vista's mission to provide investors with tools that may enable them to make profitable­ investment­ decisions with the goal to deliver investment­ considerat­ions that outperform­ small, mid and large cap equity indexes.

Please follow us on Twitter @VistaPRes­earch & Facebook at Vista-Part­ners to receive updates, thoughts and ideas about and our coverage universe of companies and more.

Disclaimer­ & Disclosure­:
For a full list of disclaimer­s and disclosure­s, please visit our website www.vistap­global.com­ or click here.  

tolles Volumen über 800.000 Stück heute gehandelt.­ Soligenix hat nur ca. 25 Mio. Aktien am Markt.  

komisch das hierzulande fast kein Interesse besteht. Sngx hat gut cash, Förderung staatl. Organisati­onen in mio Höhe, Medikament­ in Phase 3, eine Riese Pipeline, jv mit intrexon der Firma von biotech mogul Kirk uvm.  

explosionsgefahr Marketcap von ca. 25 mio. Bei den geringen float besteht hier die nächsten Wochen und Monate explosions­potential