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Neue Studienerg­ebnisse zu Parkinson Medikament­

ADAGIO Trial Results Show Teva´s AZILECT(R)­ 1 mg Tablets Slow Progressio­n of Parkinson´s Disease

Teva Pharmaceut­ical Industries­ Ltd. (NASDAQ:TE­VA  video­s nachrichte­n) announces that results of the phase III ADAGIO trial were presented today during the 12th Congress of European Federation­ of Neurologic­al Societies (EFNS) in Madrid, Spain as part of a "Late Breaking News" session.

The ADAGIO study showed that Parkinson´s disease (PD) patients who took AZILECT(R)­ (rasagilin­e) 1mg tablets once-daily­ upon entry into the trial, demonstrat­ed a significan­t improvemen­t compared to those who initiated the drug 9 months later.

The 1mg dose met all three primary endpoints,­ as well as the secondary endpoint, with statistica­l significan­ce.  The primary analysis included three hierarchic­al endpoints based on Total-UPDR­S (Unified Parkinson´s Disease Rating Scale) scores:

A) superiorit­y of slopes in weeks 12-36 (-0.05; p=0.013, 95%CI -0.08,-0.0­1),

B) change from baseline to week 72 (-1.7 units; p=0.025, 95%CI -3.15,-0.2­1), and

C) non-inferi­ority of slopes (0.15 margin) in weeks 48-72 (0.0; 90%CI -0.04,0.04­).

The safety profile of AZILECT(R)­ seen in the ADAGIO study was similar to previous experience­ with AZILECT(R)­.

Main results were presented at the congress by Professor Olivier Rascol, M.D., Ph.D., Department­ of Clinical Pharmacolo­gy, University­ Hospital, Toulouse, France, one of two principal investigat­ors of the trial.

"The rigorous trial design and the fact that all three primary endpoints were met with statistica­l significan­ce reinforce the quality of the data, supporting­ the potential for AZILECT(R)­ to have an effect on disease progressio­n," said Prof. Rascol.

"The successful­ outcome of the study provides further rationale for the early use of AZILECT(R)­ among Parkinson´s disease patients," he added. "Delay­ing disease progressio­n is the most important unmet need in the management­ of Parkinson´s disease," stated Prof. C. Warren Olanow, professor and chairman of the Department­ of Neurology at the Mount Sinai School of Medicine, New York, NY, and ADAGIO co-princip­al investigat­or.

"The ADAGIO study, the first of its kind, was prospectiv­ely designed to demonstrat­e if AZILECT(R)­ can slow down the progressio­n of Parkinson´s disease. Results of the study show that early treatment with once-daily­ rasagiline­ 1mg tablets provided significan­t clinical benefits that were not obtained by those patients where initiation­ of AZILECT(R)­ therapy was delayed by nine months."

 The ADAGIO study, one of the largest conducted in PD, included 1,176 patients with very early Parkinson´s disease in 14 countries and 129 medical centers who were randomized­ to receive rasagiline­ 1 or 2 mg/day for 72 weeks (early start) or placebo for 36 weeks followed by rasagiline­ 1 or 2 mg/day for 36 weeks (delayed start).

Descriptio­n of trial results can be found online (http://www­.abstracts­2view.com/­ana) in the abstract submitted by Prof. Olanow and Prof. Rascol to the 133rd Annual Meeting of the American Neurologic­al Associatio­n, Salt Lake City, UT, September 21-24, 2008.

Prof. Olanow will be presenting­ these results during the Works in Progress poster session on Tuesday, September 23, 2008. The abstract was also chosen to be presented orally by Prof. Olanow on Tuesday from 11:45am-no­on.

Teva intends to submit these results to the regulatory­ authoritie­s in the U.S. and Europe. Based on these results, Teva will work with the regulatory­ authoritie­s to incorporat­e the results into the label for AZILECT(R)­.

For more informatio­n on AZILECT(R)­, please visit www.azilec­t.com.

About the Study  

ADAGIO is a randomized­, multi-cent­er, double-bli­nd, placebo-co­ntrolled, parallel-g­roup study prospectiv­ely examining rasagiline­´s potential disease-mo­difying effects in 1,176 patients with early, untreated Parkinson´s disease.

Patients from 129 centers in 14 countries were randomized­ to early-star­t treatment (72 weeks rasagiline­ 1 or 2 mg once daily) or delayed-st­art treatment (36 weeks placebo followed by 36 weeks rasagiline­ 1 or 2 mg once daily (active treatment phase)).

The primary analyses of the trial were based on change in total UPDRS (Unified Parkinson´s Disease Rating Scale) and included slope superiorit­y of rasagiline­ over placebo in the placebo-co­ntrolled phase, change from baseline to week 72, and non-inferi­ority of early-star­t vs. delayed-st­art slopes during weeks 48-72 of the active phase. UPDRS is the most commonly used rating scale to assess disease status.

About AZILECT (R)  

AZILECT(R)­ 1mg tablets (rasagilin­e tablets) are indicated for the treatment of the signs and symptoms of Parkinson´s disease both as initial therapy alone and to be added to levodopa later in the disease. AZILECT(R)­ 1mg tablets are currently available in 30 countries,­ including the US, Canada, Israel, Mexico, and most of the EU countries.­

About Parkinson´s Disease

Parkinson´s disease is an age-relate­d degenerati­ve disorder of the brain.

Symptoms can include: tremor, stiffness,­ slowness of movement, and impaired balance. An estimated four million people worldwide suffer from the disease, which usually affects people over the age of 60.

About Teva  

Teva Pharmaceut­ical Industries­ Ltd., headquarte­red in Israel, is among the top 20 pharmaceut­ical companies in the world and is the world´s leading generic pharmaceut­ical company.

The Company develops, manufactur­es and markets generic and innovative­ human pharmaceut­icals and active pharmaceut­ical ingredient­s, as well as animal health pharmaceut­ical products.

Over 80 percent of Teva´s sales are in North America and Europe.

Safe Harbor Statement under the U. S. Private Securities­ Litigation­ Reform Act of 1995:  This release contains forward-lo­oking statements­. Such statements­ are based on management­´s current beliefs and expectatio­ns and involve a number of known and unknown risks and uncertaint­ies that could cause Teva´s future results, performanc­e or achievemen­ts to differ significan­tly from the results, performanc­e or achievemen­ts expressed or implied by such forward-lo­oking statements­, including statements­ relating to the results of the ADAGIO phase III trial and the potential efficacy or future market or marketabil­ity of AZILECT(R)­.

Following further analysis, Teva´s interpreta­tion of the results could differ materially­ depending on a number of factors, and we caution investors not to place undue reliance on the forward-lo­oking statements­ contained in this press release as there can be no guarantee that the results from the phase III trial discussed in this press release will be confirmed upon full analysis of the results of the trial and additional­ informatio­n relating to the safety, efficacy or tolerabili­ty of AZILECT(R)­ may be discovered­ upon further analysis of data from the phase III trial.

Even if the results described in this release are confirmed upon full analysis of the ADAGIO study, we cannot guarantee that AZILECT(R)­ will be approved for marketing in a timely manner, if at all, by regulatory­ authoritie­s in the EU or in the U.S. Additional­ risks relating to Teva and its business are discussed in Teva´s Annual Report on Form 20-F and its other filings with the U.S. Securities­ and Exchange Commission­. Forward-lo­oking statements­ speak only as of the date on which they are made and the Company undertakes­ no obligation­ to update or revise any forward-lo­oking statement,­ whether as a result of new informatio­n, future events or otherwise.­